|
Mutation Information
|
Mutation Site
|
T116N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
A |
|
Viral Reference
|
GQ477480;
GQ331048;
DQ298165;
AF043580;
AF297621;
DQ315786;
AB246317;
AY934774 |
|
Country
|
Philippines |
Literature Information
|
PubMed PMID
|
24009186
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
Journal of medical virology |
|
Title
|
Unique surface gene variants of hepatitis B virus isolated from patients in the Philippines. |
|
Author
|
Baclig MO,Alvarez MR,Gopez-Cervantes J,Natividad FF |
|
Evidence
|
Out of the 23 isolates, 15 (65%) exhibited single or multiple substitutions, which resulted to specific amino acid changes as follows: Tyrosine (Y) to Cysteine (C) at position 100, Glutamine (Q) to Lysine (K) at position 101, Glycine (G) to Serine (S) at position 102, Methionine (M) to Isoleucine (I) at position 103, Leucine (L) to Proline (P) at position 109, Isoleucine (I) to Leucine (L) at position 110, Leucine (L) to Isoleucine (I) at position 110, Threonine (T) to Serine (S) at position 113, Threonine (T) to Asparagine (N) at position 116, Serine (S) to Arginine (R) at position 117, Isoluecine (I) to Threonine (T) at position 126, Isoleucine (I) to Serine (S) at position 126, Proline (P) to Threonine (T) at position 127, Glycine (G) to Serine (S) at position 130, Methionine (M) to Threonine (T) at position 133, Phenylalanine (F) to Isoleucine (I) at position 134, Serine (S) to Leucine (L) at position 136, and Aspartic acid (D) to Alanine (A) at position 144 as shown in Figures 1-3.
|
|
|
HBV Mutation Detail Information