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Mutation Information
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Mutation Site
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T115N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
S |
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Genotype/Subtype
|
D |
|
Immune Escape
|
Y |
Literature Information
|
PubMed PMID
|
32102257
|
|
Disease
|
HBV infection
|
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Published Year
|
2020 |
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Journal
|
Viruses |
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Title
|
A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition in Vitro. |
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Author
|
Salpini R,Piermatteo L,Battisti A,Colagrossi L,Aragri M,Yu La Rosa K,Bertoli A,Saccomandi P,Lichtner M,Marignani M,Maylin S,Delaugerre C,Morisco F,Coppola N,Marrone A,Iapadre N,Cerva C,Aquaro S,Angelico M,Sarmati L,Andreoni M,Verheyen J,Ceccherini-Silberstein F,Levrero M,Perno CF,Belloni L,Svicher V |
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Evidence
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These NLGSs are located in the major hydrophilic region of HBsAg (known to be the target of antibodies) and resulted from the single mutation T115N, T117N, T123N, N114ins, and from the triple mutant S113N+T131N+M133T.
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HBV Mutation Detail Information