HBV Mutation Detail Information

> T115N Search Result

Mutation Information

Mutation Site	T115N
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Genotype/Subtype	D
Country	Italy

Literature Information

PubMed PMID	25418031
Disease	HBV infection
Published Year	2015
Journal	Hepatology (Baltimore, Md.)
Title	Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression.
Author	Salpini R,Colagrossi L,Bellocchi MC,Surdo M,Becker C,Alteri C,Aragri M,Ricciardi A,Armenia D,Pollicita M,Di Santo F,Carioti L,Louzoun Y,Mastroianni CM,Lichtner M,Paoloni M,Esposito M,D'Amore C,Marrone A,Marignani M,Sarrecchia C,Sarmati L,Andreoni M,Angelico M,Verheyen J,Perno CF,Svicher V
Evidence	This decrease was >90% (compared to WT) for four of five glycosylation sites analyzed (98.5% for T115N, 94.1% for ins115N,92% for T123N, and 90.2% for T117N1+ins114N) by using the Bio-Rad assay and for three of five glycosylation sites (99.9% for T115N, 94.7% for ins115N, and 99.4% for T123N) by using the Architect assay (Fig. 3).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation