HBV Mutation Detail Information

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Mutation Information

Mutation Site	T115A
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	16928212
Disease	Chronic hepatitis B
Published Year	2006
Journal	Journal of gastroenterology and hepatology
Title	Association of core promoter mutations with viral breakthrough in chronic hepatitis B patients on long-term lamivudine therapy.
Author	Kazim SN,Chauhan R,Das BC,Sarin SK
Evidence	Apart from the YMDD mutation, other lamivudine associated mutations of the polymerase gene resulted in S207R (Fig.2f) in two patients, F220L (Fig.2h) and C221G (Fig.2h) in one patient, S193L (Fig.2c) in one patient, W182Stop (Fig.2b) and F219S (Fig.2g) in one patient, E164D (Fig.2a) in two patients and T115A in one patient within the HBsAg.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation