|
Mutation Information
|
Mutation Site
|
T109I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
C |
|
Combined Mutation
|
c.L108I+c.T109I;c.I105V+c.L108I+c.T109I;c.E113D+c.L108I+c.T109I |
|
Genotype/Subtype
|
C |
Literature Information
|
PubMed PMID
|
28401569
|
|
Published Year
|
2017 |
|
Journal
|
Journal of medical virology |
|
Title
|
Influences on viral replication and sensitivity to GLS4, a HAP compound, of naturally occurring T109/V124 mutations in hepatitis B virus core protein. |
|
Author
|
Wang J,Zhang H,Zhang Y,Jiang D,Li J,Goldmann S,Ren Q,Fei R,Wang X,Wei L |
|
Evidence
|
T109I single mutation and all T109S/M/C/N mutations impaired HBeAg secretion.
|
|
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HBV Mutation Detail Information