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Mutation Information
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Mutation Site
|
S8R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Nef |
|
Country
|
Uganda |
Literature Information
|
PubMed PMID
|
32925973
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
PLoS pathogens |
|
Title
|
Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5. |
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Author
|
Jin SW,Mwimanzi FM,Mann JK,Bwana MB,Lee GQ,Brumme CJ,Hunt PW,Martin JN,Bangsberg DR,Ndung'u T,Brumme ZL,Brockman MA |
|
Evidence
|
To confirm that this loss of function was not particular to HIV subtype B, we introduced S8R or I/V11G substitutions into selected subtype A, C and D Nef clones that displayed normal abilities to internalize SERINC3.
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HIV Mutation Detail Information