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Mutation Information
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Mutation Site
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S84A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpr |
Literature Information
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PubMed PMID
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32753492
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Published Year
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2020 |
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Journal
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mBio |
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Title
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HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair. |
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Author
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Li D,Lopez A,Sandoval C,Nichols Doyle R,Fregoso OI |
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Evidence
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These include HIV-1 W54R/HIV-2 L59A Vpr mutants, which block the ability of HIV-1 Vpr to recruit and degrade the DNA glycosylase UNG2;HIV-1 Q65R/HIV-2 Q70R Vpr, which renders Vpr unable to properly localize, multimerize, or recruit known host proteins, such as the Cul4ADCAF1 complex or UNG2 and, therefore, is largely functionally dead;HIV-1 S79A/HIV-2 S84A mutants, which render Vpr unable to cause cell cycle arrest or interact with TAK1 to activate canonical NF-kappaB;and HIV-1 R80A/HIV-2 R85A Vpr mutants, which can still interact with Cul4ADCAF1 and degrade TET2 but do not cause cell cycle arrest, presumably due to the requirement of an additional unknown host protein(s).
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HIV Mutation Detail Information