|
Mutation Information
|
Mutation Site
|
S79A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Vpr |
|
Genotype/Subtype
|
G |
Literature Information
|
PubMed PMID
|
32753492
|
|
Published Year
|
2020 |
|
Journal
|
mBio |
|
Title
|
HIV Vpr Modulates the Host DNA Damage Response at Two Independent Steps to Damage DNA and Repress Double-Strand DNA Break Repair. |
|
Author
|
Li D,Lopez A,Sandoval C,Nichols Doyle R,Fregoso OI |
|
Evidence
|
When testing for the effects of Vpr on DNA replication, we found that, in addition to HIV-1 Q65R/HIV-2 Q70R Vpr, HIV-1 S79A/HIV-2 S84A Vpr mutants were unable to stall DNA replication (Fig. 6C), suggesting that activation of TAK1 is integral in the ability of Vpr to stall DNA replication.
|
|
|
HIV Mutation Detail Information