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Mutation Information
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Mutation Site
|
S78C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
NC_001526.4
|
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
30161236
|
|
Disease
|
Cervical carcinoma;
Squamous-cell carcinoma;
Head and neck carcinoma
|
|
Published Year
|
2018 |
|
Journal
|
PloS one |
|
Title
|
Differences in the viral genome between HPV-positive cervical and oropharyngeal cancer. |
|
Author
|
LeConte BA,Szaniszlo P,Fennewald SM,Lou DI,Qiu S,Chen NW,Lee JH,Resto VA |
|
Evidence
|
However, we found three reoccurring mutations, pinpointing potential hotspots: the substitution of serine78 to cysteine (S78C) in E6 that was found in four oropharyngeal samples, H51N in E7 occurring in two oropharyngeal samples, and the K4T/R55W pair of mutations in E6 that was identified in two oropharyngeal samples, interestingly, in the same pairing.
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HPV Mutation Detail Information