|
Mutation Information
|
Mutation Site
|
S74G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
C |
|
Genotype/Subtype
|
B |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
33453326
|
|
Disease
|
Occult HBV infection
|
|
Published Year
|
2021 |
|
Journal
|
Journal of hepatology |
|
Title
|
Role of core protein mutations in the development of occult HBV infection. |
|
Author
|
Chen J,Liu B,Tang X,Zheng X,Lu J,Zhang L,Wang W,Candotti D,Fu Y,Allain JP,Li C,Li L,Li T |
|
Evidence
|
An analysis of the effect of Cp mutants on intracellular or extracellular viral protein production indicated that the W62R mutation in Cp had a critical impact on the reduction of HBcAg and HBeAg production during HBV replication, whereas P50H and/or S74G mutations played a limited role in influencing viral protein production invivo.
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|
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HBV Mutation Detail Information