Mutation Information
Mutation Site
|
S68G |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
PR |
Relevant Drug
|
NRTIs;NNRTIs |
Literature Information
PubMed PMID
|
32053707
|
Published Year
|
2020 |
Journal
|
PLoS pathogens |
Title
|
HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle. |
Author
|
Jurczyszak D,Zhang W,Terry SN,Kehrer T,Bermúdez González MC,McGregor E,Mulder LCF,Eckwahl MJ,Pan T,Simon V |
Evidence
|
NL4-3-Δenv-eGFP MDR1 and MDR2 encode the following drug resistance associated mutations (MDR1 Protease: L10V, I13V, G16A, K20R, E35D, M36I, R41K, I64V, H69K, A71V, I84V, L90M, I93M;MDR1 RT: E6K, V35K, M41L, K49R, I50V, L74V, L100I, K103N, K122E, D123E, I135L;MDR2 Protease: I13V, I64V, V77I, L90M;MDR2 RT: M41L, K43E, S68G, V106A, K122E, D123E, I135T, see also Table 1).
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