Mutation Information
Mutation Site
|
S68G |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.K65R+rt.S68G |
Genotype/Subtype
|
AE |
Relevant Drug
|
tenofovir (TDF);lamivudine (LAM);efavirenz (EFV) |
Country
|
China |
Literature Information
PubMed PMID
|
32046664
|
Disease
|
HIV infection/AIDS
|
Published Year
|
2020 |
Journal
|
BMC infectious diseases |
Title
|
The S68G polymorphism is a compensatory mutation associated with the drug resistance mutation K65R in CRF01_AE strains. |
Author
|
Li S,Ouyang J,Zhao B,An M,Wang L,Ding H,Zhang M,Han X |
Evidence
|
The S68G polymorphism is a compensatory mutation associated with the drug resistance mutation K65R in CRF01_AE strainsThe rate of S68G mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase has increased and is closely related to the K65R mutation among CRF01_AE-infected patients who failed treatment.
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