HIV Mutation Detail Information

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Mutation Information

Mutation Site	S653T
Mutation Type	Amino acid level
Gene/Protein/Region Type	Pol
Immune Escape	Y
Country	Vietnam

Literature Information

PubMed PMID	33031103
Disease	HIV infection/AIDS
Published Year	2021
Journal	AIDS (London, England)
Title	Critical effect of Pol escape mutations associated with detrimental allele HLA-C*15: 05 on clinical outcome in HIV-1 subtype A/E infection.
Author	Murakoshi H,Chikata T,Akahoshi T,Zou C,Borghan MA,Van Tran G,Nguyen TV,Van Nguyen K,Kuse N,Takiguchi M
Evidence	We identified HLA-C∗15:05-restricted SL9 epitope including Pol 653/657. PolS653A/T/L mutations within this epitope critically impaired the T-cell recognition of HIV-1-infected cells, indicating that these mutations had escaped from the T cells.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation