|
Mutation Information
|
Mutation Site
|
S653K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Pol |
|
Immune Escape
|
Y |
|
Country
|
Vietnam |
Literature Information
|
PubMed PMID
|
33031103
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2021 |
|
Journal
|
AIDS (London, England) |
|
Title
|
Critical effect of Pol escape mutations associated with detrimental allele HLA-C*15: 05 on clinical outcome in HIV-1 subtype A/E infection. |
|
Author
|
Murakoshi H,Chikata T,Akahoshi T,Zou C,Borghan MA,Van Tran G,Nguyen TV,Van Nguyen K,Kuse N,Takiguchi M |
|
Evidence
|
T-cell responders infected with these mutants showed significantly lower CD4+ T-cell counts than those with the wild-type virus or Pol S653K/Q mutants, which are not associated with HLA-C∗15:05.
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HIV Mutation Detail Information