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Mutation Information
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Mutation Site
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S640H |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
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Gp41 |
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Viral Reference
|
HxB2
|
|
Country
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France |
Literature Information
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PubMed PMID
|
33872329
|
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Disease
|
HIV infection/AIDS
|
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Published Year
|
2021 |
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Journal
|
PLoS pathogens |
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Title
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Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis. |
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Author
|
Armani-Tourret M,Zhou Z,Gasser R,Staropoli I,Cantaloube-Ferrieu V,Benureau Y,Garcia-Perez J,Pérez-Olmeda M,Lorin V,Puissant-Lubrano B,Assoumou L,Delaugerre C,Lelièvre JD,Lévy Y,Mouquet H,Martin-Blondel G,Alcami J,Arenzana-Seisdedos F,Izopet J,Colin P,Lagane B |
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Evidence
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Several features in the sequence of F8 Env could explain this result, such as the lack of the N295 glycan at the base of V3, a K-to-E substitution at position 490 in the C5 region of gp120, and several mutations within the HR2 region of gp41 (S640H and L and N residues at positions 641 and 644) (S3D Fig).
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HIV Mutation Detail Information