HPV Mutation Detail Information

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Mutation Information

Mutation Site	S63Y
Mutation Type	Amino acid level
Gene/Protein/Region Type	E7
Amino acid_Mutation	C190A
Genotype/Subtype	HPV16
Viral Reference	K02718.1
Country	French Guiana

Literature Information

PubMed PMID	33238632
Disease	High grade squamous intraepithelial lesion; Low grade squamous intraepithelial lesion
Published Year	2020
Journal	Microorganisms
Title	E6/E7 Sequence Diversity of High-Risk Human Papillomaviruses in Two Geographically Isolated Populations of French Guiana.
Author	Nacher M,Godefroy G,Dufit V,Douine M,Najioullah F,Césaire R,Thomas N,Drak Alsibai K,Adenis A,Lacoste V
Evidence	The E6 sequences presented among themselves nine nucleotide substitutions of which five nonsynonymous associated with four amino acid changes at positions 10, 14, 78, and 83 (numbers here and thereafter refer to amino acid positions relative to the first methionine of the protein of interest), whereas E7 sequences presented four substitutions of which two non-synonymous at positions 29 and 63, N29S and S63Y (amino acid changes are based on HPV16 reference sequence, GenBank accession number K02718).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation