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Mutation Information
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Mutation Site
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S61Q |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpu |
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Viral Reference
|
AF324493.2
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Literature Information
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PubMed PMID
|
17676996
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Published Year
|
2007 |
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Journal
|
PLoS pathogens |
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Title
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Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles. |
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Author
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Estrabaud E,Le Rouzic E,Lopez-Vergès S,Morel M,Belaïdouni N,Benarous R,Transy C,Berlioz-Torrent C,Margottin-Goguet F |
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Evidence
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Introduction of Vpu S61Q mutation in the NL4-3 provirus extended the half-life of the Vpu protein;whereas, as previously reported, S52A and S56A mutations hardly affected the degradation rate of the protein (Figure 4A and 4B).
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HIV Mutation Detail Information