Mutation Information
Mutation Site
|
S61A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Vpu |
Viral Reference
|
AF324493.2
|
Literature Information
PubMed PMID
|
17676996
|
Published Year
|
2007 |
Journal
|
PLoS pathogens |
Title
|
Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles. |
Author
|
Estrabaud E,Le Rouzic E,Lopez-Vergès S,Morel M,Belaïdouni N,Benarous R,Transy C,Berlioz-Torrent C,Margottin-Goguet F |
Evidence
|
In support of this hypothesis, the Vpu S61A mutant strongly accumulated in cells as compared to the wild-type protein (Figure 3D, compare lane 2 to 4).
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