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Mutation Information
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Mutation Site
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S56N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpu |
Literature Information
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PubMed PMID
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21237475
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Published Year
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2011 |
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Journal
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Virology |
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Title
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BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action. |
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Author
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Skasko M,Tokarev A,Chen CC,Fischer WB,Pillai SK,Guatelli J |
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Evidence
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The expression of Vpu-2/6, which contains two substitutions (S52N and S56N) in the DSGXXS motif within the cytoplasmic domain, resulted in an intermediate down-regulation of surface BST-2 expression consistent with previous findings (Figure 1A and C).
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HIV Mutation Detail Information