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Mutation Information
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Mutation Site
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S46P |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Tat |
Literature Information
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PubMed PMID
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29792216
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Published Year
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2018 |
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Journal
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Retrovirology |
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Title
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HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription. |
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Author
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Ivanov A,Lin X,Ammosova T,Ilatovskiy AV,Kumari N,Lassiter H,Afangbedji N,Niu X,Petukhov MG,Nekhai S |
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Evidence
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To elucidate structural consequences of Tat phosphorylation at Ser-16 and Ser-46, we performed 20 ns Molecular Dynamics (MD) simulations in a periodical water box for the CDK9/Cyclin T1/Tat protein complexes in which Tat was non-phosphorylated on Ser-16 and Ser-46 (S16&S46) or double phosphorylated (S16P&S46P).
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HIV Mutation Detail Information