HIV Mutation Detail Information

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Mutation Information

Mutation Site	S46F
Mutation Type	Amino acid level
Gene/Protein/Region Type	Tat
Country	India

Literature Information

PubMed PMID	24465566
Disease	HIV infection/AIDS
Published Year	2014
Journal	PloS one
Title	Molecular and genetic characterization of natural HIV-1 Tat Exon-1 variants from North India and their functional implications.
Author	Ronsard L,Lata S,Singh J,Ramachandran VG,Das S,Banerjea AC
Evidence	Despite high amino acid conservation, some interesting mutations were observed in various functional domains which included K24T, H29Y and L35P mutations in cysteine-rich region with 1.000, 1.000 and 0.333 allelic frequencies respectively; G44S and S46F mutations in the core region with 30% and 20% of variants respectively; P68L mutation in all variants in the glutamine rich region which was neither seen with Tat B nor Tat C consensus sequences.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation