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Mutation Information
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Mutation Site
|
S442D |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
EBNA2 |
Literature Information
|
PubMed PMID
|
28408983
|
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Published Year
|
2017 |
|
Journal
|
F1000Research |
|
Title
|
Recent advances in understanding Epstein-Barr virus. |
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Author
|
Stanfield BA,Luftig MA |
|
Evidence
|
Indeed, it has been shown that a single amino acid change in the transactivation domain of EBV-2 EBNA2 (S442D) can drastically alter EBV-2 B-cell transformation efficacy similar to that observed with EBV-1 and increase induction of LMP1 expression with a higher affinity for the LMP1 promoter.
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EBV Mutation Detail Information