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Mutation Information
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Mutation Site
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S37N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
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Relevant Drug
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darunavir (DRV) |
Literature Information
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PubMed PMID
|
27992544
|
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Published Year
|
2016 |
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Journal
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PloS one |
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Title
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Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics. |
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Author
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Agniswamy J,Louis JM,Roche J,Harrison RW,Weber IT |
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Evidence
|
Comparison of the DRV-bound complexes of PRS17 and wild type PR/DRV shows a large conformational change in the hinge loop region (residues 34-42) associated with mutations E35D, M36I and S37N in PRS17 (Fig 3A).
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HIV Mutation Detail Information