Mutation Information
Mutation Site
|
S330R |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
E1 |
Genotype/Subtype
|
HPV16 |
Literature Information
PubMed PMID
|
9223484
|
Published Year
|
1997 |
Journal
|
Journal of virology |
Title
|
Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins. |
Author
|
Yasugi T,Vidal M,Sakai H,Howley PM,Benson JD |
Evidence
|
Among these, two classes of replication-defective HPV16 E1 missense mutants were observed. One class, represented by the S330R replication-defective mutant (containing an S-to-R change at position 330), remained competent for all protein-protein interactions tested, with the exception of hUBC9 association.
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