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Mutation Information
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Mutation Site
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S309N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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LMP1 |
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Viral Reference
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V01555.2
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Literature Information
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PubMed PMID
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18986987
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Published Year
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2008 |
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Journal
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The Journal of biological chemistry |
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Title
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Tumor-derived variants of Epstein-Barr virus latent membrane protein 1 induce sustained Erk activation and c-Fos. |
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Author
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Vaysberg M,Hatton O,Lambert SL,Snow AL,Wong B,Krams SM,Martinez OM |
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Evidence
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Group A variants share the most sequence homology with B95.8 and are characterized by three mutations at aa 212 (Gly to Ser), aa 328 (Glu to Gln), and aa 366 (Ser to Thr). Group B variants are defined by nine amino acid substitutions that include aa 212 (Gly to Ser), aa 229 (Ser to Thr), aa 252 (Gly to Ala), aa 309 (Ser to Asn), aa 322 (Gln to Asp), aa 334 (Gln to Arg), aa 338 (Leu to Ser), aa 352 (His to Arg), and aa 366 (Ser to Thr). Group C clones contain mutations at aa 212 (Gly to Ser), aa 309 (Ser to Asn), aa 322 (Gln to Asn), aa 334 (Gln to Arg), and aa 338 (Leu to Ser) and share the 10-aa deletion overlapping the start of the CTAR2 region (aa 346-355) with the CAO variant of LMP1.
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EBV Mutation Detail Information