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Mutation Information
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Mutation Site
|
S215Y |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.S215Y+rt.K70R+rt.D67N+rt.M41L |
Literature Information
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PubMed PMID
|
32129987
|
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Published Year
|
2020 |
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Journal
|
ACS infectious diseases |
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Title
|
Defective Strand-Displacement DNA Synthesis Due to Accumulation of Thymidine Analogue Resistance Mutations in HIV-2 Reverse Transcriptase. |
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Author
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Martín-Alonso S,Álvarez M,Nevot M,Martínez MÁ,Menéndez-Arias L |
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Evidence
|
In contrast, mutants D67N/K70R/S215Y and M41L/D67N/K70R/S215Y were the most defective RTs in reactions carried out with nicked and gapped substrates.
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HIV Mutation Detail Information