EBV Mutation Detail Information

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Mutation Information

Mutation Site	S186T
Mutation Type	Amino acid level
Gene/Protein/Region Type	BZLF1

Literature Information

PubMed PMID	10233912
Published Year	1999
Journal	Journal of virology
Title	Amino acid substitutions reveal distinct functions of serine 186 of the ZEBRA protein in activation of early lytic cycle genes and synergy with the Epstein-Barr virus R transactivator.
Author	Francis A,Ragoczy T,Gradoville L,Heston L,El-Guindy A,Endo Y,Miller G
Evidence	One mutant class, represented by Z(S186T), was similar to the wild type, although reduced in the capacity to activate BRLF1 and BMRF1 early lytic cycle genes from the latent virus. A second class, represented by Z(S186C) and Z(S186G), was impaired in transcriptional activation, unable to activate early lytic cycle products from the latent virus, and not rescued by overexpression of Rta.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation