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Mutation Information
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Mutation Site
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S186A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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BZLF1 |
Literature Information
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PubMed PMID
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23077295
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Published Year
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2013 |
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Journal
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Journal of virology |
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Title
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Essential role of Rta in lytic DNA replication of Epstein-Barr virus. |
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Author
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El-Guindy A,Ghiassi-Nejad M,Golden S,Delecluse HJ,Miller G |
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Evidence
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We found that Z(S186A), a mutant of ZEBRA unable to activate transcription of Rta or viral genes encoding replication proteins, is competent to bind to oriLyt and to function as an origin recognition protein. Ectopic expression of the six components of the EBV lytic replication machinery failed to rescue replication by Z(S186A).
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EBV Mutation Detail Information