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Mutation Information
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Mutation Site
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S186A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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BZLF1 |
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Viral Reference
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NC007605.1
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Literature Information
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PubMed PMID
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18369464
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Published Year
|
2008 |
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Journal
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PLoS pathogens |
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Title
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Methylated DNA recognition during the reversal of epigenetic silencing is regulated by cysteine and serine residues in the Epstein-Barr virus lytic switch protein. |
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Author
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Karlsson QH,Schelcher C,Verrall E,Petosa C,Sinclair AJ |
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Evidence
|
An independent mutation of C189 to alanine (ZtaC189A) also resulted in decreased binding to meZRE3, suggesting that the decreased binding of the C189S mutant was due to loss of the cysteine and not, for example, merely due to phosphorylation of the newly introduced serine.
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EBV Mutation Detail Information