HIV Mutation Detail Information

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Mutation Information

Mutation Site	S178A
Mutation Type	Amino acid level
Gene/Protein/Region Type	CA

Literature Information

PubMed PMID	18605989
Published Year	2008
Journal	Retrovirology
Title	VSV-G pseudotyping rescues HIV-1 CA mutations that impair core assembly or stability.
Author	Brun S,Solignat M,Gay B,Bernard E,Chaloin L,Fenard D,Devaux C,Chazal N,Briant L
Evidence	Here, we show that infectivity of HIV-1 mutants bearing S149A and S178A mutations in CA can be efficiently restored when pseudotyped with vesicular stomatitis virus envelope glycoprotein, that addresses the mutant cores through the endocytic pathway rather than by fusion at the plasma membrane.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation