HBV Mutation Detail Information

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Mutation Information
Mutation Site S167L
Mutation Type Amino acid level
Gene/Protein/Region Type S
Genotype/Subtype A
Country Spain
Literature Information
PubMed PMID 22666402
Disease Chronic hepatitis B
Published Year 2012
Journal PloS one
Title Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome.
Author Rodriguez-Frías F,Tabernero D,Quer J,Esteban JI,Ortega I,Domingo E,Cubero M,Camós S,Ferrer-Costa C,Sánchez A,Jardí R,Schaper M,Homs M,Garcia-Cehic D,Guardia J,Esteban R,Buti M
Evidence These 20 variants did not include the immune escape variant sG145R, detected in relatively high frequencies at pre-treatment, but otherwise included the variants sS167L, sW172C, and sW172*, located at the minimal recognized sequence (positions s165 to s172) of the TH-s156/s175 epitope [27]; among these, sS167L showed a continuous percentage increase from pre-treatment to ETV-VBK (sample 4A: 0.2%, 4B: 0.7%, 4C: 1.1%, 4D: 1.3%, 4E: 4%).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation