Mutation Information
Mutation Site
|
S162C |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Genotype/Subtype
|
B |
Immune Escape
|
Y |
Country
|
Europe;Italy;Asia; Africa;North America;South America |
Literature Information
PubMed PMID
|
30356083
|
Disease
|
HIV infection/AIDS
|
Published Year
|
2018 |
Journal
|
Scientific reports |
Title
|
Genetic divergence of HIV-1 B subtype in Italy over the years 2003-2016 and impact on CTL escape prevalence. |
Author
|
Alteri C,Fabeni L,Scutari R,Berno G,Di Carlo D,Gori C,Bertoli A,Vergori A,Mastrorosa I,Bellagamba R,Mussini C,Colafigli M,Montella F,Pennica A,Mastroianni CM,Girardi E,Andreoni M,Antinori A,Svicher V,Ceccherini-Silberstein F,Perno CF,Santoro MM |
Evidence
|
Interestingly, CTL escape variants occur at seven of these positions, such as the PR position 71 (escape variant: A71V), and the RT positions 35 (escape variant: V35I), 162 (escape variant: S162ACQR), 177 (escape variant: D177E), 202 (escape variant: I202V), 207 (escape variant: Q207GE) and 211 (escape variant: R211K).
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