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Mutation Information
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Mutation Site
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S154L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
S |
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Country
|
Italy |
Literature Information
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PubMed PMID
|
23796863
|
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Disease
|
HBV infection
|
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Published Year
|
2013 |
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Journal
|
The Journal of infection |
|
Title
|
Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen. |
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Author
|
Cento V,Van Hemert F,Neumann-Fraune M,Mirabelli C,Di Maio VC,Salpini R,Bertoli A,Micheli V,Gubertini G,Romano S,Visca M,De Sanctis GM,Berkhout B,Marino N,Mazzotta F,Cappiello G,Spanò A,Sarrecchia C,Ceccherini-Silberstein F,Andreoni M,Angelico M,Verheyen J,Perno CF,Svicher V |
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Evidence
|
The sS154L mutation, localized in the post “a”-determinant of HBsAg protein, was absent in drug-naïve patients and present in 2.5% of drug-failure cases (p = 0.039). This mutation corresponds to residues rtI162/rtI163 in RT-protein.
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HBV Mutation Detail Information