|
Mutation Information
|
Mutation Site
|
S153Y |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Country
|
Canada |
Literature Information
|
PubMed PMID
|
33184634
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2021 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
Progressive emergence of an S153F plus R263K combination of integrase mutations in the proviral DNA of one individual successfully treated with dolutegravir. |
|
Author
|
Pham HT,Alves BM,Yoo S,Xiao MA,Leng J,Quashie PK,Soares EA,Routy JP,Soares MA,Mesplède T |
|
Evidence
|
Combining S153F or S153Y with R263K decreased integration and viral replicative capacity and conferred high levels of drug resistance against all integrase inhibitors.
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HIV Mutation Detail Information