|
Mutation Information
|
Mutation Site
|
S153Y |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
raltegravir (RAL) |
Literature Information
|
PubMed PMID
|
18702518
|
|
Published Year
|
2008 |
|
Journal
|
Biochemistry |
|
Title
|
Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants. |
|
Author
|
Marinello J,Marchand C,Mott BT,Bain A,Thomas CJ,Pommier Y |
|
Evidence
|
The aims of the present study were: 1/ to investigate and compare the effects of raltegravir and elvitegravir on the three IN-mediated reactions: 3'-processing (3'-P), strand transfer (ST) and disintegration;2/ to determine the biochemical activities of seven IN mutants (T66I, L74M, E92Q, F121Y, Q148K, S153Y and N155H) previously selected from drug-resistant patients and isolates;3/ to determine the resistance profile for raltegravir and elvitegravir in those IN mutants.
|
|
|
HIV Mutation Detail Information