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Mutation Information
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Mutation Site
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S149D |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
CA |
Literature Information
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PubMed PMID
|
31440231
|
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Published Year
|
2019 |
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Journal
|
Frontiers in microbiology |
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Title
|
Role for Gag-CA Interdomain Linker in Primate Lentiviral Replication. |
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Author
|
Doi N,Koma T,Adachi A,Nomaguchi M |
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Evidence
|
Mutant S149N could grow albeit poorly in target lymphocytic cells, but mutants S149A, S149D, and S149K did not grow at all. Consistently, S149N exhibited normal early single-cycle infectivity in indicator cells but was partially defective for virus production (late replication phase).
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HIV Mutation Detail Information