Mutation Information
Mutation Site
|
S149A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
CA |
Literature Information
PubMed PMID
|
18605989
|
Published Year
|
2008 |
Journal
|
Retrovirology |
Title
|
VSV-G pseudotyping rescues HIV-1 CA mutations that impair core assembly or stability. |
Author
|
Brun S,Solignat M,Gay B,Bernard E,Chaloin L,Fenard D,Devaux C,Chazal N,Briant L |
Evidence
|
Here, we show that infectivity of HIV-1 mutants bearing S149A and S178A mutations in CA can be efficiently restored when pseudotyped with vesicular stomatitis virus envelope glycoprotein, that addresses the mutant cores through the endocytic pathway rather than by fusion at the plasma membrane.
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