|
Mutation Information
|
Mutation Site
|
S143L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.S143L+s.P142L |
|
Genotype/Subtype
|
E |
|
Viral Reference
|
FN594748
|
|
Country
|
Italy |
Literature Information
|
PubMed PMID
|
29596494
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2018 |
|
Journal
|
PloS one |
|
Title
|
High rates of chronic HBV genotype E infection in a group of migrants in Italy from West Africa: Virological characteristics associated with poor immune clearance. |
|
Author
|
Malagnino V,Salpini R,Maffongelli G,Battisti A,Fabeni L,Piermatteo L,Colagrossi L,Fini V,Ricciardi A,Sarrecchia C,Perno CF,Andreoni M,Svicher V,Sarmati L |
|
Evidence
|
RT sequence analysis showed the presence of a number of immune escape mutations: strains from all of the patients had a serine at HBsAg position 140; 3 also had T116N, Y100C, and P142L+S143L substitutions; and 1 had a G112R substitution.
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HBV Mutation Detail Information