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Mutation Information
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Mutation Site
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S143L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
S |
Literature Information
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PubMed PMID
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20412171
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Disease
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HBV infection
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Published Year
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2010 |
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Journal
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Vox sanguinis |
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Title
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Performance evaluation of 70 hepatitis B virus (HBV) surface antigen (HBsAg) assays from around the world by a geographically diverse panel with an array of HBV genotypes and HBsAg subtypes. |
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Author
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Scheiblauer H,El-Nageh M,Diaz S,Nick S,Zeichhardt H,Grunert HP,Prince A |
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Evidence
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There was 20-fold reduced sensitivity with mutant T131I (#1010), 13- to 120-fold reduced sensitivity with mutant Q101H (#1039), and mutant S143L (#1015) revealed a marked 500- to >1000-fold sensitivity reduction in two EIAs which would have been negative if it had not been for the high HBsAg concentration in the sample (>8000 IU/ml).
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HBV Mutation Detail Information