Mutation Information
Mutation Site
|
S142P |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
S |
Literature Information
PubMed PMID
|
10596008
|
Disease
|
HBV infection
|
Published Year
|
2000 |
Journal
|
Journal of medical virology |
Title
|
Effect of variation in the common "a" determinant on the antigenicity of hepatitis B surface antigen. |
Author
|
Seddigh-Tonekaboni S,Waters JA,Jeffers S,Gehrke R,Ofenloch B,Horsch A,Hess G,Thomas HC,Karayiannis P |
Evidence
|
The variant P142S/G145R was also not bound by themonoclonal antibodies or the AUSRIA II assay even ata concentration of 310 ng/ml but the protein containinga change of proline for serine at amino acid 142 alonewas detectable using all of the monoclonal antibodies
|
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