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Mutation Information
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Mutation Site
|
S132F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
X04615;
AY123041;
AB670283;
AB670247;
AB368296;
AB362932;
AB205124;
AB198081;
AB198080;
AB198077;
AB113879;
AB033557;
AB033556;
AB033553;
AB033552;
AB033551;
AB033550;
AB026815 |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
28658511
|
|
Disease
|
Occult HBV infection
|
|
Published Year
|
2017 |
|
Journal
|
Pediatrics international : official journal of the Japan Pediatric Society |
|
Title
|
Occult hepatitis B virus infection in immunized children born to carrier mothers. |
|
Author
|
Yokoyama K,Kumagai H,Takahashi M,Nagashima S,Okamoto H,Yamagata T |
|
Evidence
|
Although no HBV mutations were identified at 1 month of age, an HBV strain with a glycine-to-arginine mutation at residue 145 in the S gene product (G145R) emerged 8 months after vaccinations and four HBIG injections. Finally, the G145R strain, with or without the S132F mutation (Table 2), became predominant at 10 months of age when she exhibited overt HBV infection.
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|
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HBV Mutation Detail Information