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Mutation Information
|
Mutation Site
|
S119T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Genotype/Subtype
|
B |
|
Relevant Drug
|
elvitegravir (EVG);raltegravir (RAL) |
|
Country
|
Finland |
Literature Information
|
PubMed PMID
|
28212411
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2017 |
|
Journal
|
PloS one |
|
Title
|
Lack of impact of pre-existing T97A HIV-1 integrase mutation on integrase strand transfer inhibitor resistance and treatment outcome. |
|
Author
|
Abram ME,Ram RR,Margot NA,Barnes TL,White KL,Callebaut C,Miller MD |
|
Evidence
|
Some secondary integrase mutations associated with resistance to EVG and/or RAL were detected as natural integrase polymorphisms, most often at very low frequencies (0.5-1%: V72T, L74M, A128T, and G163R) with few exceptions (19%: M50I;59%: S119P/G/T/R;and 3.8%: E157Q).
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HIV Mutation Detail Information