HIV Mutation Detail Information

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Mutation Information
Mutation Site S119P
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Relevant Drug INSTIs
Country Africa
Literature Information
PubMed PMID 30891603
Disease HIV infection/AIDS
Published Year 2019
Journal The Journal of antimicrobial chemotherapy
Title High predictive efficacy of integrase strand transfer inhibitors in perinatally HIV-1-infected African children in therapeutic failure of first- and second-line antiretroviral drug regimens recommended by the WHO.
Author Mboumba Bouassa RS,Mossoro-Kpinde CD,Gody JC,Veyer D,Péré H,Matta M,Robin L,Grésenguet G,Charpentier C,Bélec L
Evidence Polymorphic mutations in the IN gene were frequently observed: L101I/M, TT124A/G/N and T125A/P/V (100%) were the most represented, followed by G134D/N/S and L234I/P/V (94.4%); T112A/E/I/T/V (83.3%), D167E/N (77.7%), K136R/Q/T (66.7%), I72V (50.0%), S255D/G/N (38.9%), N222K/T, T206S and T218I/L/S (33.3%);and I135V, I208L and S119P (27.7%).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation