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Mutation Information
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Mutation Site
|
R90K |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vpr |
Literature Information
|
PubMed PMID
|
18039376
|
|
Published Year
|
2007 |
|
Journal
|
Retrovirology |
|
Title
|
Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophages. |
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Author
|
Jacquot G,Le Rouzic E,David A,Mazzolini J,Bouchet J,Bouaziz S,Niedergang F,Pancino G,Benichou S |
|
Evidence
|
However, this localization is not sufficient, since mutations within the C-terminal basic region of Vpr (Vpr-R80A and Vpr-R90K), disrupted the G2-arrest and apoptotic activities without altering NE localization.
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HIV Mutation Detail Information