Mutation Information
Mutation Site
|
R80A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Vpr |
Literature Information
PubMed PMID
|
33648539
|
Published Year
|
2021 |
Journal
|
Virology journal |
Title
|
HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7. |
Author
|
Zhou X,Monnie C,DeLucia M,Ahn J |
Evidence
|
Cell cycle analyses of HEK293T cells transfected with the Vpr mutant that is deficient for DCAF1-binding (R62D/F69A) or Vpr C-terminal mutants (residue 1-79, and R80A) confirmed this model (Fig. 5a, lower panels).
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