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Mutation Information
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Mutation Site
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R80A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vpr |
Literature Information
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PubMed PMID
|
18445273
|
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Published Year
|
2008 |
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Journal
|
Biology direct |
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Title
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14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr. |
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Author
|
Bolton DL,Barnitz RA,Sakai K,Lenardo MJ |
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Evidence
|
We found that the well-established R80A point mutant of Vpr, which lacks G2,M arrest activity [44], failed to increase Cdk1 and CyclinB1 association with 14-3-3 θ (Fig. (Fig.3A,3A, IP; Fig. Fig.3B,3B, top row).
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HIV Mutation Detail Information