HIV Mutation Detail Information

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Mutation Information

Mutation Site	R80A
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Country	Australia

Literature Information

PubMed PMID	17630831
Disease	HIV infection/AIDS
Published Year	2007
Journal	PLoS pathogens
Title	HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase.
Author	Belzile JP,Duisit G,Rougeau N,Mercier J,Finzi A,Cohen EA
Evidence	Interestingly, the classical Vpr mutants S79A and R80A that are attenuated for the induction of G2 arrest (Figure 6C) could still associate with VPRBP and DDB1 at levels comparable with that of the wild-type protein (Figure 6A, compare lane 3 with lanes 5 and 6), suggesting that the association between Vpr and the DDB1-VPRBP complex, per se, is not sufficient to block cell cycle progression.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation