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Mutation Information
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Mutation Site
|
R77A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vpr |
Literature Information
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PubMed PMID
|
10620603
|
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Published Year
|
2000 |
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Journal
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The Journal of experimental medicine |
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Title
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The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. |
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Author
|
Jacotot E,Ravagnan L,Loeffler M,Ferri KF,Vieira HL,Zamzami N,Costantini P,Druillennec S,Hoebeke J,Briand JP,Irinopoulou T,Daugas E,Susin SA,Cointe D,Xie ZH,Reed JC,Roques BP,Kroemer G |
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Evidence
|
In contrast, replacement of arginine (R) residues situated within or between the two functionally important H(S/F)RIG motifs 52 (R73A or R77A or R80A) greatly reduced the apoptogenic effect of Vpr52-96.
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HIV Mutation Detail Information