HIV Mutation Detail Information

> R73A Search Result


Mutation Information
Mutation Site R73A
Mutation Type Amino acid level
Gene/Protein/Region Type Vpr
Literature Information
PubMed PMID 10620603
Published Year 2000
Journal The Journal of experimental medicine
Title The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.
Author Jacotot E,Ravagnan L,Loeffler M,Ferri KF,Vieira HL,Zamzami N,Costantini P,Druillennec S,Hoebeke J,Briand JP,Irinopoulou T,Daugas E,Susin SA,Cointe D,Xie ZH,Reed JC,Roques BP,Kroemer G
Evidence In contrast, replacement of arginine (R) residues situated within or between the two functionally important H(S/F)RIG motifs 52 (R73A or R77A or R80A) greatly reduced the apoptogenic effect of Vpr52-96.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation