|
Mutation Information
|
Mutation Site
|
R72P |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Genotype/Subtype
|
HPV16 |
Literature Information
|
PubMed PMID
|
21672450
|
|
Published Year
|
2011 |
|
Journal
|
Acta medica portuguesa |
|
Title
|
Is there a biological plausability for p53 codon 72 polymorphism influence on cervical cancer development? |
|
Author
|
Sousa H,Santos AM,Pinto D,Medeiros R |
|
Evidence
|
A HPV16 E6 mutant, L110Q, which was unable to bind p150(Sal2), did not affect the ability of the cellular protein to bind p21(WAF1) promoter, underlining the linkage between these events.
|
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HPV Mutation Detail Information